Oxidative Stress and Cancer Heterogeneity Orchestrate NRF2 Roles Relevant for Therapy Response

Oxidative Stress and Cancer Heterogeneity Orchestrate NRF2 Roles Relevant for Therapy Response

Oxidative stress and its end-products, such as 4-hydroxynonenal (HNE), initiate activation of the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)/Kelch Like ECH Associated Protein 1 (KEAP1) signaling pathway that plays a crucial role in the maintenance of cellular redox homeostasis. However, an i...

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Bibliographic Details
Main Authors: Koraljka Gall Trošelj, Marko Tomljanović, Morana Jaganjac, Tanja Matijević Glavan, Ana Čipak Gašparović, Lidija Milković, Suzana Borović Šunjić, Brigitta Buttari, Elisabetta Profumo, Sarmistha Saha, Luciano Saso, Neven Žarković
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
4-hydroxynonenal
therapy resistance
cancer stem cells
tumor associated macrophages (TAMs)
tumor associated neutrophils (TANs)
polarization
Online Access:https://www.mdpi.com/1420-3049/27/5/1468

Internet

https://www.mdpi.com/1420-3049/27/5/1468

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