Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of <i>ob/ob</i> Mice

Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of <i>ob/ob</i> Mice

The pancreatic islets of Langerhans consist of endocrine cells that secrete peptide hormones into the blood circulation in response to metabolic stimuli. When transplanted into the anterior chamber of the eye (ACE), pancreatic islets engraft and maintain morphological features of native islets as we...

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Bibliographic Details
Main Authors: Barbara Leibiger, Tilo Moede, Ismael Valladolid-Acebes, Meike Paschen, Montse Visa, Ingo B. Leibiger, Per-Olof Berggren
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Metabolites
Subjects:
pancreatic islets
leptin
exocytosis
tissue-engineering
in vivo imaging
metabolism
Online Access:https://www.mdpi.com/2218-1989/11/6/387

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https://www.mdpi.com/2218-1989/11/6/387

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