Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.

Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.

Maternal homozygosity for three independent mutant hecate alleles results in embryos with reduced expression of dorsal organizer genes and defects in the formation of dorsoanterior structures. A positional cloning approach identified all hecate mutations as stop codons affecting the same gene, revea...

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Bibliographic Details
Main Authors: Xiaoyan Ge, Danielle Grotjahn, Elaine Welch, Jamie Lyman-Gingerich, Christiana Holguin, Eva Dimitrova, Elliot W Abrams, Tripti Gupta, Florence L Marlow, Taijiro Yabe, Anna Adler, Mary C Mullins, Francisco Pelegri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4072529?pdf=render

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http://europepmc.org/articles/PMC4072529?pdf=render

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