A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity

A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity

Abnormal activation of microtubule affinity-regulating kinase 4 (MARK4) and its phosphorylation of the microtubule-associated protein tau are believed to play a role in the pathogenesis of Alzheimer's disease, and MARK4 inhibition can be a strategy to develop disease-modifying therapy. Here we...

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Bibliographic Details
Main Authors: Toshiya Oba, Daiki Homma, Sophia Jobien M. Limlingan, Aoi Fukuchi, Akiko Asada, Taro Saito, Kanae Ando
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Neurobiology of Disease
Subjects:
Microtubule affinity-regulating kinase 4
Peptide inhibitor for protein kinases
Allosteric
Cell-membrane permeable peptides
Tau
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003509

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http://www.sciencedirect.com/science/article/pii/S0969996123003509

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