Stimulatory Effect of Tofacitinib on Bone Marrow Adipocytes Differentiation

Stimulatory Effect of Tofacitinib on Bone Marrow Adipocytes Differentiation

BackgroundSystemic inflammation is the main factor underlying secondary osteoporosis in patients with rheumatoid arthritis (RA). Janus kinase inhibitors (JAKi), such as tofacitinib (Tofa), can control systemic inflammation and may have beneficial effects on bone in various models. This might be due...

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Bibliographic Details
Main Authors: Jean-Guillaume Letarouilly, Julien Paccou, Sammy Badr, Christophe Chauveau, Odile Broux, Aline Clabaut
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
tofacitinib
rheumatoid arthritis
human bone marrow-derived stromal cells
bone marrow adipocytes
osteoblasts
differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.881699/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.881699/full

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