Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)

Crystal Structures Reveal Hidden Domain Mechanics in Protein Kinase A (PKA)

Cyclic-AMP-dependent protein kinase A (PKA) is a critical enzyme involved in various signaling pathways that plays a crucial role in regulating cellular processes including metabolism, gene transcription, cell proliferation, and differentiation. In this study, the mechanisms of allostery in PKA were...

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Bibliographic Details
Main Authors: Colin L. Welsh, Abigail E. Conklin, Lalima K. Madan
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biology
Subjects:
protein kinases
protein kinase (A)
kinase structure
catalytic domain
structural dynamics
crystal B-factors
Online Access:https://www.mdpi.com/2079-7737/12/11/1370

Internet

https://www.mdpi.com/2079-7737/12/11/1370

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