Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype

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Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyelocytic leukemia samples; however, somatic mutations...

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Bibliographic Details
Main Authors: Ling Tian, Monique Chavez, Gue Su Chang, Nichole M. Helton, Casey D. S. Katerndahl, Christopher A. Miller, Lukas D. Wartman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592440/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592440/?tool=EBI

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