Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples

Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples

DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such as maternal age and gestational weight gain, have been earlier studied w...

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Bibliographic Details
Main Authors: Essi Laajala, Viivi Halla-aho, Toni Grönroos, Ubaid Ullah Kalim, Mari Vähä-Mäkilä, Mirja Nurmio, Henna Kallionpää, Niina Lietzén, Juha Mykkänen, Omid Rasool, Jorma Toppari, Matej Orešič, Mikael Knip, Riikka Lund, Riitta Lahesmaa, Harri Lähdesmäki
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Epigenetics
Subjects:
dna methylation
bisulphite sequencing
rrbs
umbilical cord blood
pregnancy
sex
spatial correlation
type 1 error
differential methylation
analysis workflow
Online Access:http://dx.doi.org/10.1080/15592294.2022.2044127

Internet

http://dx.doi.org/10.1080/15592294.2022.2044127

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