Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model

Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model

Growth and differentiation factor 15 (GDF15) is a cytokine reported to cause anorexia and weight loss in animal models. Neutralization of GDF15 was efficacious in mitigating cachexia and improving survival in cachectic tumor models. Interestingly, elevated circulating GDF15 was reported in patients...

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Bibliographic Details
Main Authors: Bina Albuquerque, Xian Chen, Dinesh Hirenallur-Shanthappa, Yang Zhao, John C. Stansfield, Bei B. Zhang, Abdul Sheikh, Zhidan Wu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
GDF15
cardiac cachexia
monocrotaline
Online Access:https://www.mdpi.com/2073-4409/11/7/1073

Internet

https://www.mdpi.com/2073-4409/11/7/1073

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