Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma

Vitamin D Reverts the Exosome-Mediated Transfer of Cancer Resistance to the mTOR Inhibitor Everolimus in Hepatocellular Carcinoma

Several multi-kinase inhibitors were widely tested as potential first-line or second-line therapy in patients with advanced hepatocellular carcinoma (HCC). However, acquired drug resistance limits their clinical efficacy. Exosomes are microvesicles secreted by tumor and stromal cells that participat...

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Bibliographic Details
Main Authors: Mariarosaria Negri, Feliciana Amatrudo, Annalisa Gentile, Roberta Patalano, Tatiana Montò, Cristina de Angelis, Chiara Simeoli, Rosa Pirchio, Renata Simona Auriemma, Annamaria Colao, Rosario Pivonello, Claudia Pivonello
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
exosomes
HCC
everolimus
drug resistance
PI3K/Akt/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.874091/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.874091/full

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