B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin

B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin

Abstract Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic cancer. Family with sequence similarity 83 member A (FAM83A) was shown recently to have oncogenic effects in a variety of cancer types, but the biological roles and molecular...

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Bibliographic Details
Main Authors: Cefan Zhou, Xiaoting Zhu, Nanxi Liu, Xueying Dong, Xuewen Zhang, Huili Huang, Yu Tang, Shicheng Liu, Mengyu Hu, Ming Wang, Xiaoling Deng, Shi Li, Rui Zhang, Yuan Huang, Hao Lyu, Shuai Xiao, Sang Luo, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Zhentian Wang, Jingfeng Tang
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01268-5

Internet

https://doi.org/10.1038/s41392-022-01268-5

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