A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Summary: Activation of nucleic acid sensing Toll-like receptors (TLRs) in B cells is involved in antiviral responses by promoting B cell activation and germinal center responses. In order to take advantage of this natural pathway for vaccine development, synthetic pathogen-like antigens (PLAs) const...

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Bibliographic Details
Main Authors: Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports Medicine
Subjects:
COVID-19
SARS-CoV-2
RBD
vaccine
B cells
Toll-like receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121003165

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http://www.sciencedirect.com/science/article/pii/S2666379121003165

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