Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma

Dynamic single-cell RNA-seq analysis reveals distinct tumor program associated with microenvironmental remodeling and drug sensitivity in multiple myeloma

Abstract Background Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells. Despite extensive research, molecular mechanisms in MM that drive drug sensitivity and clinic outcome remain elusive. Results Single-cell RNA sequencing was applie...

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Bibliographic Details
Main Authors: Mengping Chen, Yike Wan, Xin Li, Jing Xiang, Xiaotong Chen, Jinxing Jiang, Xiaofeng Han, Lu Zhong, Fei Xiao, Jia Liu, Honghui Huang, Hua Li, Junling Liu, Jian Hou
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cell & Bioscience
Subjects:
Multiple myeloma
Single-cell RNA sequencing
Transcriptional profiling
Drug sensitivity
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13578-023-00971-2

Internet

https://doi.org/10.1186/s13578-023-00971-2

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