Prevalent Variants in the LDLR Gene Impair Responsiveness to Rosuvastatin among Family Members of Patients with Premature Myocardial Infarction

Prevalent Variants in the LDLR Gene Impair Responsiveness to Rosuvastatin among Family Members of Patients with Premature Myocardial Infarction

Background: Familial hypercholesterolemia (FH) is an inherited metabolic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-c) from birth. About 85% of all FH cases are caused by pathogenic variants in the LDLR gene. Individuals with FH have increased cardiovascular ri...

Full description

Bibliographic Details
Main Authors: Nguyen Trung Kien, Tran Tin Nghia, Nguyen Minh Hoang, Tran Nguyen Trong Phu, Pham Thi Ngoc Nga, Ha Thi Thao Mai, J. Luis Espinoza
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Journal of Personalized Medicine
Subjects:
LDLR gene variant
familial hypercholesterolemia
rosuvastatin
premature acute myocardial infarction
genetic metabolic disease
Online Access:https://www.mdpi.com/2075-4426/13/12/1725

Internet

https://www.mdpi.com/2075-4426/13/12/1725

Similar Items