Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease

β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons. Synapses are important targets of β-amyloid, a...

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Bibliographic Details
Main Author: Davide Tampellini
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2010.00013/full