Synapses, synaptic activity and intraneuronal Aβ in Alzheimer's disease
β-amyloid peptide accumulation plays a central role in the pathogenesis of Alzheimer’s disease. Aberrant β-amyloid buildup in the brain has been shown to be present both in the extracellular space and within neurons. Synapses are important targets of β-amyloid, a...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2010-05-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2010.00013/full |