Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5’ Leader Pre-tRNA Recognition

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5’ Leader Pre-tRNA Recognition

Ribonuclease P (RNase P) is a universal RNA-protein endonuclease that catalyzes 5’ precursor-tRNA (ptRNA) processing. The RNase P RNA plays the catalytic role in ptRNA processing; however, the RNase P protein is required for catalysis in vivo and interacts with the 5’ leader sequence. A single P RNA...

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Bibliographic Details
Main Authors: Danyun Zeng, Ainur Abzhanova, Benjamin P. Brown, Nicholas J. Reiter
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
ribonuclease P
solution NMR
tRNA processing
substrate recognition
diffusion coefficient
folding
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.730274/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.730274/full

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