Aβ solubility and deposition during AD progression and in APP×PS-1 knock-in mice

Aβ solubility and deposition during AD progression and in APP×PS-1 knock-in mice

Amnestic mild cognitive impairment (MCI) appears to be a very early stage of Alzheimer’s disease (AD). The amyloid-β peptide (Aβ) is believed to be a possible substrate for AD, but little is currently known about Aβ alterations in MCI and how these changes compare to later stages of disease. In the...

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Bibliographic Details
Main Authors: M. Paul Murphy, Tina L. Beckett, Qunxing Ding, Ela Patel, William R. Markesbery, Daret K. St Clair, Harry LeVine, III, Jeffrey N. Keller
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer’s disease
Amyloid-β peptide
Amyloid precursor protein
Mild cognitive impairment
Neuritic plaque
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001106

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http://www.sciencedirect.com/science/article/pii/S0969996107001106

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