Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability

Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability

Therapy of hormone receptor positive breast cancer (BCa) generally targets estrogen receptor (ER) function and signaling by reducing estrogen production or by blocking its interaction with the ER. Despite good long-term responses, resistance to treatment remains a significant issue, with approximate...

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Bibliographic Details
Main Authors: Sarah A. Jeffreys, Branka Powter, Bavanthi Balakrishnar, Kelly Mok, Patsy Soon, André Franken, Hans Neubauer, Paul de Souza, Therese M. Becker
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
breast cancer
<i>ESR1</i>
proteasome
posttranslational modifications
endocrine therapy
Online Access:https://www.mdpi.com/2073-4409/9/9/2077

Internet

https://www.mdpi.com/2073-4409/9/9/2077

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