Protein Dimerization Generates Bistability in Positive Feedback Loops

Bistability plays an important role in cellular memory and cell-fate determination. A positive feedback loop can generate bistability if it contains ultrasensitive molecular reactions. It is often difficult to detect bistability based on such molecular mechanisms due to its intricate interaction wit...

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Bibliographic Details
Main Authors: Chieh Hsu, Vincent Jaquet, Mumun Gencoglu, Attila Becskei
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308415