Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway

Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway

Numerous studies have revealed that oxidative stress is closely associated with the occurrence and development of depression. Xiaoyao Pills (XYW) are included in the Chinese Pharmacopoeia and are frequently used for treating anxiety and depression by smoothing the liver, strengthening the spleen, an...

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Bibliographic Details
Main Authors: Yafei Ji, Jie Luo, Jiuseng Zeng, Yang Fang, Rong Liu, Fei Luan, Nan Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
xiaoyao pills
depression
olfactory bulbectomized rats
oxidative stress
inflammatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.643456/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.643456/full

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