PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia

PRDX6-iPLA2 aggravates neuroinflammation after ischemic stroke via regulating astrocytes-induced M1 microglia

Abstract The crosstalk between astrocytes and microglia plays a pivotal role in neuroinflammation following ischemic stroke, and phenotypic distribution of these cells can change with the progression of ischemic stroke. Peroxiredoxin (PRDX) 6 phospholipase A2 (iPLA2) activity is involved in the gene...

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Bibliographic Details
Main Authors: Li Peng, Yanyan Ji, Yixin Li, Yan You, Yang Zhou
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
PRDX6-iPLA2
Astrocytes
Microglia
Nox2
Drp1‑ dependent mitchondrial fission
Online Access:https://doi.org/10.1186/s12964-024-01476-2

Internet

https://doi.org/10.1186/s12964-024-01476-2

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