α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parki...

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Bibliographic Details
Main Authors: Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04422-2

Internet

https://doi.org/10.1038/s41467-018-04422-2

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