Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

Hepatic metastases are a poor prognostic factor of colorectal carcinoma (CRC) and new strategies to reduce the risk of liver CRC colonization are highly needed. Herein, we used mouse models of hepatic metastatization to demonstrate that the continuous infusion of therapeutic doses of interferon-alph...

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Bibliographic Details
Main Authors: Ngoc Lan Tran, Lorena Maria Ferreira, Blanca Alvarez-Moya, Valentina Buttiglione, Barbara Ferrini, Paola Zordan, Andrea Monestiroli, Claudio Fagioli, Eugenia Bezzecchi, Giulia Maria Scotti, Antonio Esposito, Riccardo Leone, Chiara Gnasso, Andrea Brendolan, Luca G Guidotti, Giovanni Sitia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
liver metastases
colorectal cancer
interferon-alpha
HECs
LSECs
cross-priming
Online Access:https://elifesciences.org/articles/80690

Internet

https://elifesciences.org/articles/80690

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