Predominant VH1-69 IgBCR Clones Show Higher Expression of CD5 in Heterogeneous Chronic Lymphocytic Leukemia Populations

Predominant VH1-69 IgBCR Clones Show Higher Expression of CD5 in Heterogeneous Chronic Lymphocytic Leukemia Populations

The immunoglobulin B cell receptor (IgBCR) expressed by chronic lymphocytic leukemia (CLL) B cells plays a pivotal role in tumorigenesis, supporting neoplastic transformation, survival, and expansion of tumor clones. We demonstrated that in the same patient, two or more CLL clones could coexist, rec...

Full description

Bibliographic Details
Main Authors: Domenico Maisano, Enrico Iaccino, Alessandro D’Ambrosio, Federico Chiurazzi, Vincenzo Dattilo, Mariangela Scalise, Massimo Gentile, Eleonora Vecchio, Nancy Nisticò, Annamaria Aloisio, Erika De Sensi, Giuseppe Fiume, Ileana Quinto, Selena Mimmi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia
phage display
immunoglobulin B cell receptor
peptide-based sorting
gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.703254/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.703254/full

Similar Items