Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-...

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Bibliographic Details
Main Authors: Mar Álvarez, Enrique Sapena-Ventura, Joanna Luczkowiak, Samara Martín-Alonso, Luis Menéndez-Arias
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
HIV
reverse transcriptase
antiretroviral drug resistance
DNA synthesis
doravirine
RNase H
Online Access:https://www.mdpi.com/1999-4915/13/1/131

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https://www.mdpi.com/1999-4915/13/1/131

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