Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells

Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells

Background: Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated. Methods: HT-29 cells were exposed to the IC50 concentration of hierridin B (100.2 μM)...

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Bibliographic Details
Main Authors: Sara Freitas, Rosário Martins, Margarida Costa, Pedro N. Leão, Rui Vitorino, Vitor Vasconcelos, Ralph Urbatzka
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Marine Drugs
Subjects:
natural products
bioactive compounds
anticancer drugs
colon cancer cells
marine cyanobacteria
mitochondria
vdac1
cell cycle
proteomics
high content analysis
Online Access:http://www.mdpi.com/1660-3397/14/9/158

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http://www.mdpi.com/1660-3397/14/9/158

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