Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors

Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors

Summary: CD8+ T cells mediate acute rejection of allografts, which threatens the long-term survival of transplanted organs. Using MHC class I tetramers, we find that allogeneic CD8+ T cells are present at an elevated naive precursor frequency relative to other epitopes, only modestly increase in num...

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Bibliographic Details
Main Authors: Gregory S. Cohen, Melissa A. Kallarakal, Sahana Jayaraman, Francis I. Ibukun, Katherine P. Tong, Linda D. Orzolek, H. Benjamin Larman, Scott M. Krummey
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723010045

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http://www.sciencedirect.com/science/article/pii/S2211124723010045

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