Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布)
用ICAM-1(Intercellular adhesion molecule-1)和S-100 免疫组织化学技术,Ishigami 分级记数和统计学分析方法,研究结肠癌淋巴转移时细胞间粘附分子-1在淋巴管内皮细胞中的表达和树突状细胞(Dendritic cells,DCs)的分布.正常结肠组织淋巴管内皮细胞ICAM-1表达阴性,癌组织淋巴管内皮细胞ICAM-1表达呈阳性.随着癌组织浸润深度的增加,ICAM-1阳性淋巴管数目逐渐增多(P<0.01).当肠周淋巴结有癌转移时,ICAM-1阳性淋巴管明显多于无癌转移组(p<0.01);与ICAM-1的表达相反,树突状细胞(DCs)局部浸...
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| Format: | Article |
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Zhejiang University Press
2003-05-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
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| Online Access: | https://doi.org/zjup/1008-9497.2003.30.3.327-331 |
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| author | SUZhi-hong(宿志弘) LIJi-cheng(李继承) JIYi-ming(季一鸣) |
| author_facet | SUZhi-hong(宿志弘) LIJi-cheng(李继承) JIYi-ming(季一鸣) |
| author_sort | SUZhi-hong(宿志弘) |
| collection | DOAJ |
| description | 用ICAM-1(Intercellular adhesion molecule-1)和S-100 免疫组织化学技术,Ishigami 分级记数和统计学分析方法,研究结肠癌淋巴转移时细胞间粘附分子-1在淋巴管内皮细胞中的表达和树突状细胞(Dendritic cells,DCs)的分布.正常结肠组织淋巴管内皮细胞ICAM-1表达阴性,癌组织淋巴管内皮细胞ICAM-1表达呈阳性.随着癌组织浸润深度的增加,ICAM-1阳性淋巴管数目逐渐增多(P<0.01).当肠周淋巴结有癌转移时,ICAM-1阳性淋巴管明显多于无癌转移组(p<0.01);与ICAM-1的表达相反,树突状细胞(DCs)局部浸润强度与癌组织浸润深度呈负相关(r=-0.62,p<0.01),肠周淋巴结无癌转移组DCs数目多于有淋巴结转移组(P<0.01). ICAM-1的表达和DCs的分布与结肠癌的浸润和淋巴转移有密切关系,并对结肠癌的治疗和预后均有重要的临床意义. |
| first_indexed | 2024-04-24T17:02:38Z |
| format | Article |
| id | doaj.art-66a81545b4d5496bb6e007755ff103bd |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T17:02:38Z |
| publishDate | 2003-05-01 |
| publisher | Zhejiang University Press |
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| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-66a81545b4d5496bb6e007755ff103bd2024-03-29T01:58:20ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972003-05-01303327331zjup/1008-9497.2003.30.3.327-331Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布)SUZhi-hong(宿志弘)0LIJi-cheng(李继承)1JIYi-ming(季一鸣)2 1.Institute of Cell Biology, Zhejiang University, Hangzhou 310031, China( 1.浙江大学细胞生物学研究所，浙江 杭州 310031) 1.Institute of Cell Biology, Zhejiang University, Hangzhou 310031, China( 1.浙江大学细胞生物学研究所，浙江 杭州 310031) 2.Xianju People's Hospital, Xianju 317300, China( 2.仙居人民医院，浙江 仙居 317300)用ICAM-1(Intercellular adhesion molecule-1)和S-100 免疫组织化学技术,Ishigami 分级记数和统计学分析方法,研究结肠癌淋巴转移时细胞间粘附分子-1在淋巴管内皮细胞中的表达和树突状细胞(Dendritic cells,DCs)的分布.正常结肠组织淋巴管内皮细胞ICAM-1表达阴性,癌组织淋巴管内皮细胞ICAM-1表达呈阳性.随着癌组织浸润深度的增加,ICAM-1阳性淋巴管数目逐渐增多(P<0.01).当肠周淋巴结有癌转移时,ICAM-1阳性淋巴管明显多于无癌转移组(p<0.01);与ICAM-1的表达相反,树突状细胞(DCs)局部浸润强度与癌组织浸润深度呈负相关(r=-0.62,p<0.01),肠周淋巴结无癌转移组DCs数目多于有淋巴结转移组(P<0.01). ICAM-1的表达和DCs的分布与结肠癌的浸润和淋巴转移有密切关系,并对结肠癌的治疗和预后均有重要的临床意义.https://doi.org/zjup/1008-9497.2003.30.3.327-331结肠癌细胞间粘附分子-1树突状细胞s-100蛋白淋巴转移 |
| spellingShingle | SUZhi-hong(宿志弘) LIJi-cheng(李继承) JIYi-ming(季一鸣) Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) Zhejiang Daxue xuebao. Lixue ban 结肠癌 细胞间粘附分子-1 树突状细胞 s-100蛋白 淋巴转移 |
| title | Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) |
| title_full | Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) |
| title_fullStr | Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) |
| title_full_unstemmed | Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) |
| title_short | Intercellular adhesion mdecule-1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer(结肠癌淋巴转移时细胞间粘附分子(ICAM-1)表达和树突状细胞分布) |
| title_sort | intercellular adhesion mdecule 1 expression and dendritic cell distribution in lymphatic metastasis of colon cancer 结肠癌淋巴转移时细胞间粘附分子 icam 1 表达和树突状细胞分布 |
| topic | 结肠癌 细胞间粘附分子-1 树突状细胞 s-100蛋白 淋巴转移 |
| url | https://doi.org/zjup/1008-9497.2003.30.3.327-331 |
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