Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells

Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells

Epidermal growth factor receptor (EGFR) inhibitors have limited efficacy in head and neck squamous cell carcinoma (HNSCC) due to various resistance mechanisms, such as activation of the insulin-like growth factor-1 receptor (IGF1R), which initiates pro-survival signaling. Survivin, a member of the i...

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Bibliographic Details
Main Authors: Christine E. Lehman, Rolando E. Mendez, Michael I. Dougherty, Amir Allak, Oluwayemisi L. Adejumo, Linnea E. Taniguchi, Ashraf Khalil, Daniel G. Gioeli, Mark J. Jameson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Oncology
Subjects:
survivin
IGF1R
lapatinib
EGFR
HNSCC
resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00013/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00013/full

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