A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl nucleoside shed from Mycobacterium tuberculosis, 1...

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Bibliographic Details
Main Authors: Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-03-01
Series:The Journal of Clinical Investigation
Subjects:
Infectious disease
Microbiology
Online Access:https://doi.org/10.1172/JCI161944

Internet

https://doi.org/10.1172/JCI161944

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