Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly

Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly

Misoriented division of neuroprogenitors, by loss-of-function studies of centrosome or spindle components, has been linked to the developmental brain defects microcephaly and lissencephaly. As these approaches also affect centrosome biogenesis, spindle assembly, or cell-cycle progression, the result...

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Bibliographic Details
Main Authors: Huaibiao Li, Torsten Kroll, Jürgen Moll, Lucien Frappart, Peter Herrlich, Heike Heuer, Aspasia Ploubidou
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
oriented division
cerebral neuroprogenitor
cerebral cortex
cerebellar granule cell precursor
cerebellum differentiation
neurogenesis
brain development
RHAMM
neuronal progenitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303703

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http://www.sciencedirect.com/science/article/pii/S2213671117303703

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