Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies

Combining skin and olfactory α-synuclein seed amplification assays (SAA)—towards biomarker-driven phenotyping in synucleinopathies

Abstract Seed amplification assays (SAA) are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity in the olfactory epithelium than in CSF or skin....

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Bibliographic Details
Main Authors: A. Kuzkina, J. Rößle, A. Seger, C. Panzer, A. Kohl, V. Maltese, T. Musacchio, S. J. Blaschke, G. Tamgüney, S. Kaulitz, K. Rak, A. Scherzad, P. H. Zimmermann, J. P. Klussmann, S. Hackenberg, J. Volkmann, C. Sommer, M. Sommerauer, K. Doppler
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00519-8

Internet

https://doi.org/10.1038/s41531-023-00519-8

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