Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role of FLS circadian clock function in directing rhyt...

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Bibliographic Details
Main Authors: Polly Downton, Suzanna H. Dickson, David W. Ray, David A. Bechtold, Julie E. Gibbs
Format: Article
Language:English
Published: The Royal Society 2024-07-01
Series:Open Biology
Subjects:
rheumatoid arthritis
circadian clock
inflammation
matrix metalloprotease
fibroblast-like synoviocytes
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.240089

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https://royalsocietypublishing.org/doi/10.1098/rsob.240089

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