Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases

Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases

Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency,...

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Bibliographic Details
Main Authors: Hazel Quek, Anthony R White
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
human in vitro microglia models; neurodegeneration; neuroinflammation; patient heterogeneity; patient stratification; peripheral blood monocyte-derived microglia-like cells; therapeutic target; transdifferentiation; translational outcomes
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=955;epage=958;aulast=Quek

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=955;epage=958;aulast=Quek

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