Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases
Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency,...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=955;epage=958;aulast=Quek |
| _version_ | 1798018321332830208 |
|---|---|
| author | Hazel Quek Anthony R White |
| author_facet | Hazel Quek Anthony R White |
| author_sort | Hazel Quek |
| collection | DOAJ |
| description | Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency, or physiological relevance, which deterred successful therapeutic outcomes for the past decade. Here we review human blood monocyte-derived microglia-like cells as a robust and consistent approach to generate a patient-specific microglia-like model that can be used in extensive cohort studies for drug testing. We will highlight the strength and applicability of human blood monocyte-derived microglia-like cells to increase translational outcomes by reviewing the advantages of human blood monocyte-derived microglia-like cells in addressing patient heterogeneity and stratification, the basis of personalized medicine. |
| first_indexed | 2024-04-11T16:22:12Z |
| format | Article |
| id | doaj.art-66b56488f2f042c6a7be0e13ee32f95b |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-11T16:22:12Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-66b56488f2f042c6a7be0e13ee32f95b2022-12-22T04:14:17ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-0118595595810.4103/1673-5374.355740Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseasesHazel QuekAnthony R WhiteMicroglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency, or physiological relevance, which deterred successful therapeutic outcomes for the past decade. Here we review human blood monocyte-derived microglia-like cells as a robust and consistent approach to generate a patient-specific microglia-like model that can be used in extensive cohort studies for drug testing. We will highlight the strength and applicability of human blood monocyte-derived microglia-like cells to increase translational outcomes by reviewing the advantages of human blood monocyte-derived microglia-like cells in addressing patient heterogeneity and stratification, the basis of personalized medicine.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=955;epage=958;aulast=Quekhuman in vitro microglia models; neurodegeneration; neuroinflammation; patient heterogeneity; patient stratification; peripheral blood monocyte-derived microglia-like cells; therapeutic target; transdifferentiation; translational outcomes |
| spellingShingle | Hazel Quek Anthony R White Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases Neural Regeneration Research human in vitro microglia models; neurodegeneration; neuroinflammation; patient heterogeneity; patient stratification; peripheral blood monocyte-derived microglia-like cells; therapeutic target; transdifferentiation; translational outcomes |
| title | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases |
| title_full | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases |
| title_fullStr | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases |
| title_full_unstemmed | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases |
| title_short | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases |
| title_sort | patient specific monocyte derived microglia as a screening tool for neurodegenerative diseases |
| topic | human in vitro microglia models; neurodegeneration; neuroinflammation; patient heterogeneity; patient stratification; peripheral blood monocyte-derived microglia-like cells; therapeutic target; transdifferentiation; translational outcomes |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=5;spage=955;epage=958;aulast=Quek |
| work_keys_str_mv | AT hazelquek patientspecificmonocytederivedmicrogliaasascreeningtoolforneurodegenerativediseases AT anthonyrwhite patientspecificmonocytederivedmicrogliaasascreeningtoolforneurodegenerativediseases |