Bioassay-guided isolation and in Silico characterization of cytotoxic compounds from Hemimycale sp. Sponge targeting A549 lung cancer cells

Bioassay-guided isolation and in Silico characterization of cytotoxic compounds from Hemimycale sp. Sponge targeting A549 lung cancer cells

Abstract Bioassay-guided fractionation approach led to identification of two novel compounds; (4-(hydroxymethyl)-3-methoxy-1H-pyrazol (1) and mycalene (2), alongside with four known metabolites; octadecane (3), hexatriacontane (4), 1-heneicosanol (5) and heptatriacontanoic acid (6) from the Red Sea...

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Bibliographic Details
Main Authors: Asmaa Abo Elgoud Said, Islam M. Abdel-Rahman, Yaser A. Mostafa, Eman Zekry Attia, Mamdouh Nabil Samy, Usama Ramadan Abdelmohsen, Katsuyoshi Matsunami, Mostafa A. Fouad, Yaser G. Gouda
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Chemistry
Subjects:
Red sea
Marine sponge
Hemimycale
Cytotoxicity
NMR
In silico
Online Access:https://doi.org/10.1186/s13065-024-01325-w

Internet

https://doi.org/10.1186/s13065-024-01325-w

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