Structure Activity Relationship of Phenolic Acid inhibitors of α-Synuclein Fibril Formation and Toxicity

Structure Activity Relationship of Phenolic Acid inhibitors of α-Synuclein Fibril Formation and Toxicity

The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson’s disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies. Although the...

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Bibliographic Details
Main Authors: Mustafa eArdah, Katerina ePaleologou, Guohua eLv, Salema eAbul Khair, Abdullah eAl Kendi, Saeed eMinhas, Taleb eAl-Tel, Abdulmonem eAl-Hayani, Mohammed eHaque, David eEliezer, Omar eEl-Agnaf
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Drug Discovery
Gallic Acid
Aggregation
Parkinson’s disease
α-Synuclein
Amyloid fibrils
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00197/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00197/full

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