The <i>Clostridium botulinum</i> C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells

The <i>Clostridium botulinum</i> C2 Toxin Subunit C2IIa Delivers Enzymes with Positively Charged N-Termini into the Cytosol of Target Cells

The binary <i>Clostridium</i> (<i>C.</i>) <i>botulinum</i> C2 toxin consists of two non-linked proteins. The proteolytically activated binding/transport subunit C2IIa forms barrel-shaped homoheptamers, which bind to cell surface receptors, mediate endocytosis, and...

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Bibliographic Details
Main Authors: Sebastian Heber, Joscha Borho, Nicole Stadler, Fanny Wondany, Irina König, Jens Michaelis, Panagiotis Papatheodorou, Holger Barth, Maximilian Fellermann
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Toxins
Subjects:
bacterial AB-type protein toxins
cytosolic drug delivery
molecular Trojan horse
<i>Clostridium botulinum</i> C2 toxin
C2IIa
polyhistidine-tag
Online Access:https://www.mdpi.com/2072-6651/15/6/390

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https://www.mdpi.com/2072-6651/15/6/390

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