Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies
The outer layer of the skin, the epidermis, is the principal barrier to the external environment: post-mitotic cells terminally differentiate to form a tough outer cornified layer of enucleate and flattened cells that confer the majority of skin barrier function. Nuclear degradation is required for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
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| Series: | Journal of Developmental Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2221-3759/8/4/29 |
| _version_ | 1797545663081218048 |
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| author | Duncan Wotherspoon Clare Rogerson Ryan F.L. O’Shaughnessy |
| author_facet | Duncan Wotherspoon Clare Rogerson Ryan F.L. O’Shaughnessy |
| author_sort | Duncan Wotherspoon |
| collection | DOAJ |
| description | The outer layer of the skin, the epidermis, is the principal barrier to the external environment: post-mitotic cells terminally differentiate to form a tough outer cornified layer of enucleate and flattened cells that confer the majority of skin barrier function. Nuclear degradation is required for correct cornified envelope formation. This process requires mRNA translation during the process of nuclear destruction. In this review and perspective, we address the biology of transcriptional bursting and the formation of ribonuclear particles in model organisms including mammals, and then examine the evidence that these phenomena occur as part of epidermal terminal differentiation. |
| first_indexed | 2024-03-10T14:18:26Z |
| format | Article |
| id | doaj.art-66bbd2cbecfd4e74a06bfc13a08ba408 |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-03-10T14:18:26Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-66bbd2cbecfd4e74a06bfc13a08ba4082023-11-20T23:32:56ZengMDPI AGJournal of Developmental Biology2221-37592020-12-01842910.3390/jdb8040029Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA BodiesDuncan Wotherspoon0Clare Rogerson1Ryan F.L. O’Shaughnessy2Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London E1 2AT, UKThe Francis Crick Institute, London NW1 1AT, UKCentre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London E1 2AT, UKThe outer layer of the skin, the epidermis, is the principal barrier to the external environment: post-mitotic cells terminally differentiate to form a tough outer cornified layer of enucleate and flattened cells that confer the majority of skin barrier function. Nuclear degradation is required for correct cornified envelope formation. This process requires mRNA translation during the process of nuclear destruction. In this review and perspective, we address the biology of transcriptional bursting and the formation of ribonuclear particles in model organisms including mammals, and then examine the evidence that these phenomena occur as part of epidermal terminal differentiation.https://www.mdpi.com/2221-3759/8/4/29epidermisterminal differentiationtranscriptional burstingribonuclear particles |
| spellingShingle | Duncan Wotherspoon Clare Rogerson Ryan F.L. O’Shaughnessy Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies Journal of Developmental Biology epidermis terminal differentiation transcriptional bursting ribonuclear particles |
| title | Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies |
| title_full | Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies |
| title_fullStr | Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies |
| title_full_unstemmed | Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies |
| title_short | Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies |
| title_sort | perspective controlling epidermal terminal differentiation with transcriptional bursting and rna bodies |
| topic | epidermis terminal differentiation transcriptional bursting ribonuclear particles |
| url | https://www.mdpi.com/2221-3759/8/4/29 |
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