Immunohistochemical based molecular subtypes of muscle-invasive bladder cancer: association with HER2 and EGFR alterations, neoadjuvant chemotherapy response and survival

Immunohistochemical based molecular subtypes of muscle-invasive bladder cancer: association with HER2 and EGFR alterations, neoadjuvant chemotherapy response and survival

Abstract Muscle-invasive bladder cancers (MIBCs) is a group of molecularly heterogonous diseases that could be stratified into subtypes with distinct clinical courses and sensitivities to chemotherapy. Clinical application of molecular subtypes could help in prediction of neoadjuvant chemotherapy (N...

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Bibliographic Details
Main Authors: Duaa S. Helal, Sara A. Darwish, Radwa A. Awad, Dina A. Ali, Dina M. El-Guindy
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Diagnostic Pathology
Subjects:
Muscle invasive bladder cancer
Molecular classification
GATA3,CK5/6,p53,HER2,EGFR
Luminal
Basal
Response to chemotherapy
Online Access:https://doi.org/10.1186/s13000-023-01295-y

Internet

https://doi.org/10.1186/s13000-023-01295-y

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