Silica nanoparticles induce pulmonary autophagy dysfunction and epithelial-to-mesenchymal transition via p62/NF-κB signaling pathway

Silica nanoparticles induce pulmonary autophagy dysfunction and epithelial-to-mesenchymal transition via p62/NF-κB signaling pathway

It has been reported that silica nanoparticles (SiNPs) could cause epithelial-to-mesenchymal transition (EMT), but the specific mechanism is still unclear. Thus, the purpose of this study was to investigate the underlying mechanisms of pulmonary EMT after subacute exposure to SiNPs. The results show...

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Bibliographic Details
Main Authors: Yuexiao Ma, Qingqing Liang, Fenghong Wang, Kanglin Yan, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan, Zhiwei Sun
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
SiNPs
Epithelial-to-mesenchymal transition (EMT)
Autophagy dysfunction
Pulmonary inflammation
P62/NF-κB pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322001439

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http://www.sciencedirect.com/science/article/pii/S0147651322001439

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