The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

The genome of the malaria parasite Plasmodium falciparum contains a record of past evolutionary forces. Here, using 2537 parasite sequences from the Democratic Republic of the Congo, the authors demonstrate how drug pressure and human movement have shaped the present-day parasite population.

Bibliographic Details
Main Authors: Robert Verity, Ozkan Aydemir, Nicholas F. Brazeau, Oliver J. Watson, Nicholas J. Hathaway, Melchior Kashamuka Mwandagalirwa, Patrick W. Marsh, Kyaw Thwai, Travis Fulton, Madeline Denton, Andrew P. Morgan, Jonathan B. Parr, Patrick K. Tumwebaze, Melissa Conrad, Philip J. Rosenthal, Deus S. Ishengoma, Jeremiah Ngondi, Julie Gutman, Modest Mulenga, Douglas E. Norris, William J. Moss, Benedicta A. Mensah, James L. Myers-Hansen, Anita Ghansah, Antoinette K. Tshefu, Azra C. Ghani, Steven R. Meshnick, Jeffrey A. Bailey, Jonathan J. Juliano
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15779-8

Internet

https://doi.org/10.1038/s41467-020-15779-8

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