O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells

O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells

ABSTRACT Escherichia coli K1 causes bacteremia and meningitis in human neonates. The K1 capsule, an α2,8-linked polysialic acid (PSA) homopolymer, is its essential virulence factor. PSA is usually partially modified by O-acetyl groups. It is known that O-acetylation alters the antigenicity of PSA, b...

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Bibliographic Details
Main Authors: Jinghua Yang, Wei Ma, Yuanyuan Wu, Hui Zhou, Siyu Song, Yuqi Cao, Chengxu Wang, Xiangyuan Liu, Jinwei Ren, Jinyou Duan, Zhichao Pei, Cheng Jin
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
Escherichia coli K1
O-acetylation
Siglecs
adherence
invasion
capsular polysialic acid
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00399-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.00399-21

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