C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice
Cardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease. Cardiac fibroblasts (CFs), a major cell type in the heart, are responsible for regulating normal myocardial function and maintaining extracellular matrix homeostasis in adverse myo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-07-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13212 |
| _version_ | 1818733296969842688 |
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| author | Jiao Liu Yuxuan Jin Bei Wang Jinying Zhang Shengkai Zuo |
| author_facet | Jiao Liu Yuxuan Jin Bei Wang Jinying Zhang Shengkai Zuo |
| author_sort | Jiao Liu |
| collection | DOAJ |
| description | Cardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease. Cardiac fibroblasts (CFs), a major cell type in the heart, are responsible for regulating normal myocardial function and maintaining extracellular matrix homeostasis in adverse myocardial remodeling. In this study, we found that C188‐9, a small‐molecule inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibited an antifibrotic function, both in vitro and in vivo. C188‐9 decreased transforming growth factor‐β1‐induced CF activation and fibrotic gene expression. Moreover, C188‐9 treatment alleviated heart injury and cardiac fibrosis in an isoproterenol‐induced mouse model by suppressing STAT3 phosphorylation and activation. These findings may help us better understand the role of C188‐9 in cardiac fibrosis and facilitate the development of new treatments for cardiac fibrosis and other cardiovascular diseases. |
| first_indexed | 2024-12-17T23:47:13Z |
| format | Article |
| id | doaj.art-66c36a41dec6498da3165ef09f6e9a6f |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-17T23:47:13Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-66c36a41dec6498da3165ef09f6e9a6f2022-12-21T21:28:16ZengWileyFEBS Open Bio2211-54632021-07-011172033204010.1002/2211-5463.13212C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in miceJiao Liu0Yuxuan Jin1Bei Wang2Jinying Zhang3Shengkai Zuo4Department of Cardiology First Affiliated Hospital of Zhengzhou University ChinaDepartment of Cardiology First Affiliated Hospital of Zhengzhou University ChinaDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology School of Basic Medical Sciences Tianjin Medical University ChinaDepartment of Cardiology First Affiliated Hospital of Zhengzhou University ChinaDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology School of Basic Medical Sciences Tianjin Medical University ChinaCardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease. Cardiac fibroblasts (CFs), a major cell type in the heart, are responsible for regulating normal myocardial function and maintaining extracellular matrix homeostasis in adverse myocardial remodeling. In this study, we found that C188‐9, a small‐molecule inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibited an antifibrotic function, both in vitro and in vivo. C188‐9 decreased transforming growth factor‐β1‐induced CF activation and fibrotic gene expression. Moreover, C188‐9 treatment alleviated heart injury and cardiac fibrosis in an isoproterenol‐induced mouse model by suppressing STAT3 phosphorylation and activation. These findings may help us better understand the role of C188‐9 in cardiac fibrosis and facilitate the development of new treatments for cardiac fibrosis and other cardiovascular diseases.https://doi.org/10.1002/2211-5463.13212C188‐9cardiac fibroblastscardiac fibrosisSTAT3 |
| spellingShingle | Jiao Liu Yuxuan Jin Bei Wang Jinying Zhang Shengkai Zuo C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice FEBS Open Bio C188‐9 cardiac fibroblasts cardiac fibrosis STAT3 |
| title | C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice |
| title_full | C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice |
| title_fullStr | C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice |
| title_full_unstemmed | C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice |
| title_short | C188‐9 reduces TGF‐β1‐induced fibroblast activation and alleviates ISO‐induced cardiac fibrosis in mice |
| title_sort | c188 9 reduces tgf β1 induced fibroblast activation and alleviates iso induced cardiac fibrosis in mice |
| topic | C188‐9 cardiac fibroblasts cardiac fibrosis STAT3 |
| url | https://doi.org/10.1002/2211-5463.13212 |
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