Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis

Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis

Abstract Background Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression. Methods The GSE105027 (microRNA [miRNA/miR] expression profile; 12 OA samples and 12 normal s...

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Bibliographic Details
Main Authors: Pei-yan Huang, Jun-guo Wu, Jun Gu, Tie-qi Zhang, Ling-feng Li, Si-qun Wang, Minghai Wang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
Differentially expressed genes
Differentially expressed miRNAs
Transcription factors
Regulatory network
Online Access:https://doi.org/10.1186/s13018-021-02201-2

Internet

https://doi.org/10.1186/s13018-021-02201-2

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