Targeting 4–1BB with fucoidan from Fucus vesiculosus: A strategy to activate macrophages and remodel the immunosuppressive microenvironment for pancreatic cancer therapy

Targeting 4–1BB with fucoidan from Fucus vesiculosus: A strategy to activate macrophages and remodel the immunosuppressive microenvironment for pancreatic cancer therapy

Pancreatic ductal adenocarcinoma (PDAC) presents a significant clinical challenge due to its high mortality and resistance to chemotherapy. Over the past decade, fucoidan has been explored as a potential treatment for cancers of the lung, breast, bladder, colon, and pancreas. However, investigations...

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Bibliographic Details
Main Authors: Yi Wang, Yabin Ding, Xiaomei Wei, Wenxiu Tian, Wenxiang Zheng, Yongliang Liu, Chuanqin Shi, Xinxin Xiang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Carbohydrate Polymer Technologies and Applications
Subjects:
Pancreatic cancer
Fucoidan
4–1BB
TNF signaling pathway
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S266689392500060X

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http://www.sciencedirect.com/science/article/pii/S266689392500060X

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