A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide

A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide

Abstract Background Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours. Pathogenic variants have been identified in more than 15 susceptibility genes; associated tumours are grouped into three Clusters, reinforced by their transcriptional profiles. Cluster 1A PPGLs have pa...

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Bibliographic Details
Main Authors: Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Fishbein, Roberta Noberini, Ioannis N. Anastopoulos, Nicola Tufton, Eugenie S. Lim, Rupert Obholzer, Johnathan G. Hubbard, Mufaddal Moonim, Tiziana Bonaldi, Katherine L. Nathanson, Louise Izatt, Rebecca J. Oakey
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Clinical Epigenetics
Subjects:
Phaeochromocytoma
Paraganglioma
DNA methylation
Epigenetics
Succinate dehydrogenase
Histone post-translational modifications
Online Access:https://doi.org/10.1186/s13148-023-01598-3

Internet

https://doi.org/10.1186/s13148-023-01598-3

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