Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine

As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the strategies to improve poorly absorbed drug bioavailability have attracted the attention of pharmaceutical companies. It has been demonstrated tha...

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Bibliographic Details
Main Authors: Hisanao Kishimoto, Kaori Miyazaki, Hiroshi Tedzuka, Ryosuke Ozawa, Hanai Kobayashi, Yoshiyuki Shirasaka, Katsuhisa Inoue
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
sodium nitroprusside
absorption enhancer
mucus layer
passive diffusion
lipophilic drug
Online Access:https://www.mdpi.com/1420-3049/26/21/6396

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https://www.mdpi.com/1420-3049/26/21/6396

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