HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of <i>HNF4A</i> Promoter Activity with Possible Disruption in Transcription Networks

HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of <i>HNF4A</i> Promoter Activity with Possible Disruption in Transcription Networks

Hepatocyte nuclear factor 1A (HNF1A) is the master regulator of liver homeostasis and organogenesis and regulates many aspects of hepatocyte functions. It acts as a tumor suppressor in the liver, evidenced by the increased proliferation in HNF1A knockout (KO) hepatocytes. Hence, we postulated that a...

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Bibliographic Details
Main Authors: Effi Haque, Aamir Salam Teeli, Dawid Winiarczyk, Masahiko Taguchi, Shun Sakuraba, Hidetoshi Kono, Paweł Leszczyński, Mariusz Pierzchała, Hiroaki Taniguchi
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Genes
Subjects:
hepatocellular carcinoma
mutation
HNF1A
POU domain
HNF4A
Online Access:https://www.mdpi.com/2073-4425/13/3/413

Internet

https://www.mdpi.com/2073-4425/13/3/413

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