SpotClean adjusts for spot swapping in spatial transcriptomics data

SpotClean adjusts for spot swapping in spatial transcriptomics data

Spatial transcriptomics experiments profile genome-wide gene expression at localized spots across a tissue. Here, the authors identify spot swapping, an artifact where RNA expressed at one tissue spot binds probes at another, and they propose SpotClean to adjust for it.

Bibliographic Details
Main Authors: Zijian Ni, Aman Prasad, Shuyang Chen, Richard B. Halberg, Lisa M. Arkin, Beth A. Drolet, Michael A. Newton, Christina Kendziorski
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30587-y

Internet

https://doi.org/10.1038/s41467-022-30587-y

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